When you think of comfort food, nothing beats a cozy bowl of Mac and Cheese Meatloaf Casserole. This dish combines the heartiness of meatloaf with the creamy goodness of mac and cheese, creating a meal that warms your soul. I remember the first time I tried this recipe at a family gathering; the kids couldn’t get enough of it, and neither could the adults! The aroma of melted cheese and seasoned beef filled the kitchen, making everyone feel at home. This recipe is my twist on that classic, and I can promise you that every bite is a delightful experience. It’s perfect for family dinners or potlucks. Let’s get cooking!

Why You’ll Love It
- Rich and creamy flavor profile that combines the best of meatloaf and mac and cheese.
- Easy to prepare in under 1 hour—perfect for busy weeknights!
- Great for feeding a crowd or family gatherings; everyone will want seconds.
- Budget-friendly with simple ingredients that won’t break the bank.
- Kid-friendly, making it a hit with picky eaters—who can resist cheesy goodness?
- Perfect for make-ahead meals; just pop it in the oven when you’re ready.
- One-dish meal means minimal cleanup, leaving you more time to enjoy with loved ones.
- Versatile: customize with your favorite ingredients like veggies or different cheeses!
Ingredients for Mac and Cheese Meatloaf Casserole
- Ground Beef: 1 lb (provides the protein base for a hearty meal)
- Onion: 1/2 cup, diced (adds a wonderful flavor and aroma)
- Breadcrumbs: 1/2 cup (binds the meatloaf for a perfect texture)
- Egg: 1 large (helps to hold the mixture together)
- Milk: 1/4 cup (adds moisture to the meatloaf and keeps it tender)
- Salt: 1 tsp (enhances flavor throughout the dish)
- Pepper: 1/2 tsp (adds a touch of heat and depth)
- Macaroni: 2 cups, uncooked (the base for the creamy mac and cheese)
- Cheddar Cheese: 2 cups, shredded (provides creaminess and rich flavor)
- Butter: 2 tbsp (for making a luscious cheese sauce)
- Flour: 2 tbsp (thickens the cheese sauce for that perfect consistency)
- Milk: 2 cups (for the cheese sauce, creating a creamy texture)
- Salt: 1/2 tsp (seasoning for the cheese sauce)
- Pepper: 1/4 tsp (seasoning for the cheese sauce)
- Paprika: 1/2 tsp (adds color and a subtle kick)
- Dry Mustard: 1/2 tsp (adds depth to the cheese sauce)
How to Make Mac and Cheese Meatloaf Casserole
- Step 1: Preheat your oven to 350°F (175°C). This sets the stage for a perfectly baked casserole.
- Step 2: In a large bowl, combine the ground beef, diced onion, breadcrumbs, egg, 1/4 cup milk, salt, and pepper. Mix until well combined—don’t be afraid to get your hands in there for the best texture!
- Step 3: Press the mixture into the bottom of a greased 9×13-inch baking dish, creating a solid base for your delicious meatloaf.
- Step 4: Bake for 20 minutes, until the meatloaf is slightly firm and starting to brown on the edges.
- Step 5: While the meatloaf is baking, cook the macaroni according to package directions. Drain and set aside, letting that pasta soak up all the flavors.
- Step 6: In a saucepan, melt the butter over medium heat. Stir in the flour and cook for 1 minute to form a roux. Gradually whisk in 2 cups of milk, stirring until the mixture thickens and becomes creamy.
- Step 7: Stir in 1/2 tsp salt, 1/4 tsp pepper, paprika, dry mustard, and 1 1/2 cups of shredded cheddar cheese until melted and gooey—oh, the smell is heavenly!
- Step 8: Combine the cooked macaroni with the cheesy sauce, making sure each elbow is coated in that luscious cheese goodness. Pour the mixture over the partially cooked meatloaf, ensuring even coverage for the ultimate bite.
- Step 9: Sprinkle the remaining cheese on top for that irresistible cheesy crust.
- Step 10: Return to the oven and bake for an additional 25 minutes, or until the cheese is melted and bubbly. Trust me, you’ll want to let it rest for a few minutes before diving in!
Pro Tips for the Best Mac and Cheese Meatloaf Casserole
- Use freshly shredded cheese for a smoother melt—trust me, it makes a world of difference!
- Let the casserole rest for 5-10 minutes before serving to allow it to set; this helps with slicing and serving.
- Experiment with different cheeses for unique flavors; a mix of sharp cheddar and creamy mozzarella is my personal favorite.
What’s the secret to perfect Mac and Cheese Meatloaf Casserole?
The secret lies in using a mix of cheeses. Combining sharp cheddar with a creamy cheese like mozzarella enhances both flavor and texture, making each bite a cheesy delight!
Can I make Mac and Cheese Meatloaf Casserole ahead of time?
Absolutely! You can prepare the meatloaf and cheese sauce in advance. Just assemble the casserole and store it in the fridge, then pop it in the oven when you’re ready to serve.
How do I avoid common mistakes with Mac and Cheese Meatloaf Casserole?
To avoid mishaps, don’t overmix the meatloaf mixture, as this can lead to a dense texture. Also, make sure to properly drain the macaroni after cooking to prevent a watery casserole. A little care goes a long way! For more comforting breakfast-style bakes and ideas, check out our Breakfast Recipes!
Best Ways to Serve Mac and Cheese Meatloaf Casserole
Serve the casserole hot, garnished with a sprinkle of fresh parsley for a pop of color that makes the dish even more inviting. Pair it with a simple green salad dressed lightly with vinaigrette to balance the richness of the cheesy meatloaf. For a heartier option, some steamed broccoli or green beans on the side adds a nice crunch and freshness. This dish is perfect for family dinners, potlucks, or even casual gatherings, offering a comforting one-dish meal that brings everyone together around the table. Trust me, your loved ones will be asking for seconds!
Nutrition Facts for Mac and Cheese Meatloaf Casserole
Each serving of Mac and Cheese Meatloaf Casserole contains approximately:
- Calories: 450
- Fat: 25g
- Saturated Fat: 12g
- Carbohydrates: 35g
- Fiber: 2g
- Protein: 25g
- Sugar: 3g
- Sodium: 800mg
These values are estimates and may vary based on specific ingredients used.
How to Store and Reheat Mac and Cheese Meatloaf Casserole
To keep your delicious Mac and Cheese Meatloaf Casserole fresh, store any leftovers in an airtight container in the refrigerator for up to 3 days. If you want to save it for later, you can freeze the casserole for up to 3 months. When you’re ready to enjoy it again, simply thaw it overnight in the refrigerator if it’s frozen. Then, preheat your oven to 350°F (175°C) and bake for about 20 minutes, or until it’s heated through and bubbly. For the best results, cover the casserole with foil while reheating to prevent it from drying out. Your cheesy comfort food will taste just as good as when it was first made!
Frequently Asked Questions About Mac and Cheese Meatloaf Casserole
- Can I substitute the ground beef?
Yes, you can use ground turkey, chicken, or even plant-based meat alternatives. Just keep in mind that cooking times may vary depending on the type of meat you choose, so adjust accordingly to ensure it’s cooked through. - What can I add for extra flavor?
If you’re looking to enhance the taste, consider adding garlic powder, Worcestershire sauce, or even your favorite spices to the meat mixture. A dash of hot sauce can also provide a nice kick! - Is this dish gluten-free?
To make it gluten-free, simply swap out regular breadcrumbs and pasta for gluten-free alternatives. Just be sure all other ingredients you’re using are certified gluten-free to avoid any cross-contamination. - Can I double the recipe?
Absolutely! Doubling the recipe is a great idea for larger gatherings. Just make sure to use a bigger baking dish to accommodate the extra volume, and keep an eye on cooking times as they might need a little adjustment.
Variations of Mac and Cheese Meatloaf Casserole You Can Try
- Vegetarian Version: Replace ground beef with lentils or mushrooms for a hearty texture that still satisfies.
- Spicy Mac and Cheese Meatloaf Casserole: Add diced jalapeños or a splash of hot sauce to the meat mixture for a delightful kick of heat.
- BBQ Meatloaf Casserole: Mix in your favorite BBQ sauce into the meat mixture for a smoky flavor that’ll make your taste buds dance.
- Italian Twist: Incorporate Italian seasoning and creamy mozzarella cheese for a flavorful Italian-style casserole that’s sure to impress!
For more delicious recipes and ideas, check out our Pinterest page!

Mac and Cheese Meatloaf Casserole: 7 Comforting Reasons to Savor
- Prep Time: 15 minutes
- Cook Time: 45 minutes
- Total Time: 1 hour
- Yield: 6 servings
- Category: Casserole
- Method: Baking
- Cuisine: American
- Diet: Kid-friendly
Description
A comforting casserole combining meatloaf and mac and cheese.
Ingredients
- Ground Beef: 1 lb
- Onion: 1/2 cup, diced
- Breadcrumbs: 1/2 cup
- Egg: 1 large
- Milk: 1/4 cup
- Salt: 1 tsp
- Pepper: 1/2 tsp
- Macaroni: 2 cups, uncooked
- Cheddar Cheese: 2 cups, shredded
- Butter: 2 tbsp
- Flour: 2 tbsp
- Milk: 2 cups
- Salt: 1/2 tsp
- Pepper: 1/4 tsp
- Paprika: 1/2 tsp
- Dry Mustard: 1/2 tsp
Instructions
- Preheat your oven to 350°F (175°C).
- In a bowl, combine ground beef, onion, breadcrumbs, egg, milk, salt, and pepper. Mix well and press into the bottom of a greased 9×13-inch baking dish.
- Bake for 20 minutes.
- While the meatloaf is baking, cook macaroni according to package directions. Drain and set aside.
- In a saucepan, melt butter over medium heat. Stir in flour and cook for 1 minute. Gradually whisk in milk and cook until thickened.
- Stir in salt, pepper, paprika, dry mustard, and 1 1/2 cups of cheese until melted.
- Stir cooked macaroni into cheese sauce. Pour over partially cooked meatloaf. Sprinkle remaining cheese on top.
- Return to oven and bake for an additional 25 minutes or until cheese is melted and bubbly.
Notes
- This dish is great for family dinners.
- Can be made ahead and stored in the fridge.
- Perfect for potlucks or gatherings.
Nutrition
- Serving Size: 1 serving
- Calories: 450
- Sugar: 3g
- Sodium: 800mg
- Fat: 25g
- Saturated Fat: 12g
- Unsaturated Fat: 10g
- Trans Fat: 0g
- Carbohydrates: 35g
- Fiber: 2g
- Protein: 25g
- Cholesterol: 80mg
Keywords: Mac and Cheese Meatloaf Casserole, Meatloaf mac and cheese bake, Cheesy meatloaf casserole with pasta, Macaroni and cheese meatloaf dish